Keywords: Protein Engineering, Enzyme Engineering, Display Technology, Molecular Biology, Automation
General Summary
We are seeking a skilled scientist with a background in Protein Engineering in the Bioengineering Department at BioMap. This position will mainly focus on computation-guided library generation, high-throughput screening, automation platform development, and protein/enzyme engineering.
We are a multi-disciplinary team working closely with computational scientists on nanobodies, antibodies, and enzymes, supporting the discovery of bio-therapeutics through our engineering expertise. The successful candidate has a background within protein engineering, and preferably experience with HT display methodologies in the library generation, sorting, and analysis, and automation platform development.
It's a great opportunity to collaborate with world-class biologists, AI/ML scientists, and engineers to explore next-generation therapeutical drug development.
Job Responsibilities
- Working closely with other scientists on protein/enzyme engineering projects by using yeast display, NGS, flow cytometry, liquid handler, microplate reading.
- Help design the DNA constructs, synthetic DNA libraries, and yeast/mammalian libraries.
- Generate the library by molecular biology techniques, including RT-PCR, gene cloning, yeast transformation, mammalian cell transfection, etc.
- Analyze libraries by FACS sorting and NGS to screen for lead candidate.
- Help develop the high-throughput flow cytometry and plate-reader analysis platform.
- Assist the HTP protein/enzyme characterization and assay development.
- Collaborate with cross-functional teams for project development.
- Routine laboratory instruments maintenance, including flow cytometry, PerkinElmer Liquid Handling system.
- Demonstrate ability to combine, analyze, and visualize data from multiple sources.
- Attend internal and external meeting to represent the department or company for project presentation.
Qualifications
- Bachelor’s in Biochemistry with 3+ years’ relevant experience is required. A Master’s or a Ph.D degree within subject matter expertise are preferred.
- Relevant required experience includes some combination of the following skills: Display technologies, Flow cytometry, NGS, enzyme purification.
- Good understanding of antibody and enzyme science.
- Experience with different protein formats, such as antibody, nanobody, mini-binder, and enzyme is a plus.
- Experience with iQue3 and PerkinElmer Liquid Handling system is a plus.
- Experience on protein purification system (such as AKTA) and protein characterization (SPR/BLI) is a plus.
- Familiar with industrial working standards, including LIMS is a plus.
- Demonstrates excellent verbal and written communication skills.
What we offer:
- The opportunity to work on high-impact tools and products that are immediately deployed to accelerate the discovery of new medicines
- A strong team in AI, software, and biochemistry
- Daily lunch and a full snack station
BioMap is an equal opportunity employer and values diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
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Last updated on May 1, 2024