Scientist, Molecular/Cellular Oncology

at Sonata Therapeutics

Watertown, MA USA

The Company:

WHAT IF THE SECRET OF HEALTH LIES AT THE CENTER OF DISEASE? At Sonata Therapeutics, we are designing therapeutics that reprogram diseased cells to become the coordinators of cure.   

Through a combination of our proprietary genetic library, comprehensive biochemical and functional characterization, and the latest advancements in machine learning algorithms, we are generating a deep understanding of how to reshape multicellular networks to guide the development of transformative therapeutics. While initially focused on oncology, our network-based approach is applicable across many intractable diseases.     

Sonata Therapeutics was founded by Flagship Pioneering, an organization dedicated to the origination and development of first-in-category life sciences companies.  Since 2000, Flagship has originated and fostered the development of nearly 100 scientific ventures resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.  

 

The Position:

Our team is growing, and we are on the hunt for a Scientist, Molecular/Cellular Oncology to join our Molecular/Cellular Oncology team. This position will start as a full-time contractor until the end of 2024 with the option to extend through 2025 and the potential to be hired as a full-time employee.

In this role, you will work on the bench and contribute to completing crucial data packages for target validation that will enable our novel therapeutics to go from bench to bedside. As a Scientist, you will independently design, implement and troubleshoot cell-based assays for validating Sonata’s novel targets using different perturbation technologies and various downstream readouts, including molecular and immunological assays. You will also be responsible for molecular cloning, genetic material and viral vector preparation, generation and quality control of stable cell lines for supporting in vivo target validation efforts. You will work in a dynamic, fast-paced environment where you will collaborate with interdisciplinary teams.

Sonata Therapeutics offers the challenge and opportunity to work at an early-stage, big concept biotechnology company.  You will gain experience in novel drug development from discovery to clinic and make an impact on the lives of patients and caregivers. You will develop expertise in cancer research and drug development.

 

You will be making a significant impact by...

• Molecular cloning of single genetic payloads and pooled libraries into delivery vectors
• High quality DNA and lenti-virus preparation and quality control for single genetic payloads and pooled libraries
• Cell line generation, characterization and optimization using molecular biology techniques, immunological assays and FACS
• Design, optimization and execution of cell-based assays to validate targets using different perturbation modalities (transient transfection of siRNA, transduction of lenti-virus, small molecules) and different readouts (images, flow cytometry, qPCR, and ELISA)
• Collaborating within a multidisciplinary team to drive target validations efforts in accordance with timelines, assisting other members of the team as needed.
• Contributing scientifically and culturally to a dynamic and rapidly growing research organization.

As an excellent candidate, you will possess...

• Ph.D in Cell Biology, Molecular Biology, Cancer Biology, Immunology or a related field with 0- 3 years of laboratory experience in industrial setting.
• Expertise with molecular cloning, molecular biology techniques, genetic material and lenti-viral preparation is required.
• Expertise with mammalian cell culture and related cell-based molecular and immunological assays, such as flow cytometry, qPCR, Western Blots, ELISA is required.
• Expertise with cell line generation and associated quality control is required.
• Ability to work independently to design experiments, interpret data and troubleshoot problems.
• Attention to detail, effective communication skills and the ability to work on multiple projects in a fast-moving environment and meet timelines.
• Team-oriented attitude, embracing opportunities to collaborate cross-functionally and work together to drive projects forward

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Last updated on Jun 3, 2024