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Scientist II, High Throughput Screening

scribetherapeutics · 16 days ago
$120-150k
Full-time
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Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.

We are seeking a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. The current role is for a Scientist within our high-throughput gRNA screening team. The candidate should have a passion for working collaboratively with biologists and bioengineers to enable building the necessary tools for meeting the new frontier of CRISPR-based therapeutics. Additionally, the candidate would bring expertise in mammalian cell biology, next-generation sequencing, and genome engineering to establish robust screening assays in human cells and lead therapeutic discovery efforts.

The candidate will have opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a leadership role of increasing responsibilities and the ability to publish highly impactful work in peer reviewed journals. 

Key Responsibilities:

  • Work collaboratively with our platform engineering and discovery biology teams to develop, characterize, and execute need-based novel molecular and cell based assays and readouts
  • Develop protocols to further scale-up or scale-out established assays using high-throughput, high-content, arrayed or pooled approaches
  • Support cross-functional team efforts to develop and execute strategies to address the underlying causes of disease across a range of therapeutic areas using Scribe’s genome editing platform
  • Efficiently communicate results to team members verbally and in writing
  • Effectively collaborate with members within a fully integrated team to facilitate execution on projects within established timelines
  • Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science

Required Skills and Background:

  • PhD in Bioengineering, Genomics, Molecular Biology, or equivalent
  • At least 2 years of experience working in an academic or industry lab, with a proven track record of developing and executing novel, high throughput, high content, arrayed or pooled assays in mammalian cells, preferably using CRISPR technologies
  • Experience optimizing library preparation for next-generation sequencing techniques, in addition to more common cellular and molecular assays (e.g. RT-qPCR, ddPCR, FACS, imaging, etc.)
  • An intermediate level of programming experience (preferably in Python or R) and knowledge of bioinformatic tools applied to NGS analysis  
  • Strong organizational and documentation skills, effective verbal and written communication skills, and critical problem-solving and analytical skills
  • Ability to work both independently and collaboratively in a fast-paced, interdisciplinary research team

Preferred Skills and Background:

  • Familiarity with CRISPR technologies and therapeutic approaches
  • Experience culturing primary cells, in particular primary neurons and other CNS cell-types
  • Familiarity with protein or RNA structure and engineering approaches
  • Experience with laboratory automation and robotics
  • Familiarity with viral vectors and other delivery modalities for introducing genetic material into primary cells

Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Visit us at www.scribetx.com.   

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, disability, age, or veteran status.

At the time of posting, the base pay wage range for this role is $120,000-150,000 per year.  The offered pay range will depend on internal equity and the candidate’s relevant skills, experience, qualifications, training, and market data.  Additional incentives are provided as part of the complete package in addition to comprehensive medical and other benefits.

Last updated on Feb 5, 2024

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