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Sr. Associate Scientist, Analytical Development - Mass Spectrometry & Characterization

regenxbio · 30+ days ago
Negotiable
Full-time
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Who we are

REGENXBIO is an exceptional place to work. You'll have the opportunity to collaborate with some of the best and the brightest people, touch amazing science, and be a part of extraordinary plans. Our core values: Trust, Accountability, Perseverance, and Innovation drive everything we do. We aim to bring these values to life every day with all that we do, and we believe that what we do matters - to patients, to their families, and to their communities.

The Opportunity

We are in search of a collaborative, passionate scientist with sound scientific knowledge and excellent technical skills in analytical sciences for biologics. You will be responsible for performing routine analytical tests and develop analytical methods independently. You also will be responsible to develop release, characterization, and in-process assays to support the development and manufacturing of AAV based gene therapy products. In this role, you will collaborate across multiple groups including Process Development, Quality, Formulation, Research, as well as CMOs and CTLs to ensure that all applicable analytical test methods are appropriate for the stages of clinical development.

What You'll Be Doing

  • Collaborate with a team of scientists and associates to implement analytical methods and provide analytical support for in-house and contract labs for AAV-based gene therapy products.
  • Perform routine analysis using mass spectrometry (LC-MS/MS) and biophysical methods to support release and characterization of AAV products.
  • Perform assay qualification/validation and analytical tech transfer appropriate for the stages of clinical development. These methods may include intact mass analysis, peptide mapping, analytical ultracentrifugation, light scattering, and differential scanning fluorimetry assays.
  • Make detailed observations, analyze data, interpret results, prepare reports, and exercise appropriate technical judgment in the design, execution, and interpretation of experiments.  
  • Maintain effective communication with managers, analytical groups, and cross-functional teams.
  • Keep detailed and accurate testing records.
  • Troubleshoot and resolve analytical method and instrument issues to successful resolution.

We set our employees up for success. To be successful in this role and help us achieve our goals, we are looking for someone with the following skills and qualifications:

  • Bachelor’s degree in relevant scientific discipline with at least 8+ years relevant industry experience or master’s degree in relevant scientific discipline with 5+ years of relevant industry experience or PhD in relevant scientific discipline with no industry experience.
  • Experience in mass spectrometry (LC-MS/MS), analytical ultracentrifugation (SV-AUC), particle size analysis (DLS and NTA), and thermodynamic analysis (DSF and DSC).
  • Experience in analytical method development, tech transfer, method qualification and validation are highly desired.
  • Experience in analytical method development, tech transfer, method qualification and validation are highly desired.
  • Experience drafting and reviewing technical documents including analytical method development/qualification/validation/transfer documents and SOPs.
  • Ability to independently plan and perform experiments for assay development, product release/stability/characterization, support for project activities with minimal supervision.
  • Ability to interpret data, draw conclusions, and recommend next steps.
  • Ability to effectively communicate information and results in the appropriate format (i.e. lab notebooks, presentations, etc.).
  • Prior industry experience preferred.
Why Should You Apply?

By joining REGENXBIO, you will have the opportunity to be a part of a growing company and incredible team passionate about developing novel AAV gene therapy products to our patients.

We offer a comprehensive and competitive benefit plan which includes market-competitive salaries, an annual bonus program, education assistance, retirement plan with employer match, stock options at all levels, summer hours and more!

In addition, professional development is important to us.  By joining our team, you’ll have the opportunity to be exposed to challenging projects and development resources to help you grow personally and professionally. 

Last updated on Sep 4, 2024

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